Platinum Group Metal Compounds in Cancer Chemotherapy

Announcement: 8th International Symposium on Platinum and Other Metal Coordination Compounds in Cancer Chemotherapy ISPCC '99

Platinum Co-ordination Complexes in Cancer Chemotherapy

Following its widespread adoption into clinical practice in the early 1970s the drug cispiatin (cis-diamminedichloroplatinum(II), cis[PrClfiH J2]) has improved substantially the response rate5 in a number of malignant conditions, particularly testicular and ovarian cancer. However, the clinical utility of the drug is limited by its toxic side effects. The most significant of these is kidney tox...

Cisplatin-Ifosfamide-gemcitabine as salvage chemotherapy in ovarian cancer patients pretreated with platinum compounds and Paclitaxel.

BACKGROUND The role of combination chemotherapy regimens in the management of ovarian cancer patients with tumors previously exposed to platinum compounds and paclitaxel has not yet been defined. The present phase II study evaluated the activity and toxicity of a gemcitabine-ifosfamide-cisplatin combination in the aforementioned group of patients. Given the in vitro and in vivo synergism betwee...

Paclitaxel-ifosfamide-cisplatin as salvage chemotherapy in ovarian cancer patients pretreated with platinum compounds and paclitaxel.

BACKGROUND The role of combination chemotherapy regimens in the management of ovarian cancer patients with tumors previously exposed to platinum compounds and paclitaxel has not yet been defined. The present phase II study evaluated the activity and toxicity of a paclitaxel-ifosfamide-cisplatin combination in the aforementioned group of patients. Given the in vitro and in vivo synergism between...

Metals and metal compounds in cancer treatment.

Metals and metal compounds have been used in medicine for several thousands of years. In this review we summarized the anti-cancer activities of the ten most active metals: arsenic, antimony, bismuth, gold, vanadium, iron, rhodium, titanium, gallium and platinum. The first reviewed metal, arsenic, presents the anomaly of displaying anti-cancer and oncogenic properties simultaneously. Some antim...